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Applicability of CALL score as a predictor of risk progression in patients with COVID-19 pneumonia / Heliza Marie S. Nagano.

Contributor(s): Language: english Publication details: Fairview, Quezon City; Department of Internal Medicine, FEU-NRMF, 2021.Description: 22 pages: illustrations, tables; (in folder) + with flash drive (soft copy)Content type:
  • text
Media type:
  • unmediated
Carrier type:
  • volume
Subject(s): LOC classification:
  • MED 2021 0002
Summary: Abstract: COVID-19 did affect the healthcare system in terms of its resources and capabilities. Early intervention is needed to effectively manage patients for the possibility of disease progression. This study aims to validate the CALL Score in predicting the risk progression of patient with COVID-19 pneumonia at Far Eastern University Nicanor Reyes Medical Center. Chart review was done to retrieve data of admitted patient with COVID-19 from March 2020 to February 2021. Medical charts of patients aged 18 years old and above with RT-PCR confirmed infection were included through a purposive sampling strategy. All patients were classified as low, moderate, or high risk based on their total score. Patients were grouped into two based on the disease progression (stable or progressive). Extended Chi-square or Fisher's Exact Test were used to determine significant association of the four CALL score parameters between the stable and progressive groups. The area under the ROC (AUROC) and optimal cutoff values were determined and assessed by the sensitivity, specificity, predictive values and likelihood ratios. Overall, 143 patients were divided into a stable group (n=109) and a progressive group (n=34). Generally, presence of comorbidities (p=0.001), age (p=0.0005), lymphocyte count (p<0.0001), and LDH levels (p<0.0001) were significantly different between the stable and progressive group. Using a cutoff of 6 points, the positive-predictive value (95% CI) was 30.3% (21.8=39.8%) and the negative-predictive value (95% CI) was 97.1% (84.7-99.9%) with an AUC of 0.637 (0.585, 0.697). Using a cutoff of 9 points, the positive-predictive value (95% CI) was 43.1% (30.8-56.0%) and the negative-predictive value (95% CI) was 92.3% (84.0-97.1%) with an AUC of 0.742 (0.663-0.821). AUCs of two cutoff points were found to have significant difference (p=0.0062). We found significant differences in terms of the demographic characteristics, laboratory parameters, and clinical history of stable and progressive patients based on their total CALL score. Thus, utility CALL score in the local setting might be considered for early management of COVID-19 pneumonia.
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Item type Current library Call number Status Notes Date due Barcode
Room Use Far Eastern University - Nicanor Reyes Medical Foundation Research MED 2021 0002 (Browse shelf(Opens below)) Available with flash drive (soft copy) R000827

Includes bibliographical references.

Abstract: COVID-19 did affect the healthcare system in terms of its resources and capabilities. Early intervention is needed to effectively manage patients for the possibility of disease progression. This study aims to validate the CALL Score in predicting the risk progression of patient with COVID-19 pneumonia at Far Eastern University Nicanor Reyes Medical Center. Chart review was done to retrieve data of admitted patient with COVID-19 from March 2020 to February 2021. Medical charts of patients aged 18 years old and above with RT-PCR confirmed infection were included through a purposive sampling strategy. All patients were classified as low, moderate, or high risk based on their total score. Patients were grouped into two based on the disease progression (stable or progressive). Extended Chi-square or Fisher's Exact Test were used to determine significant association of the four CALL score parameters between the stable and progressive groups. The area under the ROC (AUROC) and optimal cutoff values were determined and assessed by the sensitivity, specificity, predictive values and likelihood ratios. Overall, 143 patients were divided into a stable group (n=109) and a progressive group (n=34). Generally, presence of comorbidities (p=0.001), age (p=0.0005), lymphocyte count (p<0.0001), and LDH levels (p<0.0001) were significantly different between the stable and progressive group. Using a cutoff of 6 points, the positive-predictive value (95% CI) was 30.3% (21.8=39.8%) and the negative-predictive value (95% CI) was 97.1% (84.7-99.9%) with an AUC of 0.637 (0.585, 0.697). Using a cutoff of 9 points, the positive-predictive value (95% CI) was 43.1% (30.8-56.0%) and the negative-predictive value (95% CI) was 92.3% (84.0-97.1%) with an AUC of 0.742 (0.663-0.821). AUCs of two cutoff points were found to have significant difference (p=0.0062). We found significant differences in terms of the demographic characteristics, laboratory parameters, and clinical history of stable and progressive patients based on their total CALL score. Thus, utility CALL score in the local setting might be considered for early management of COVID-19 pneumonia.

Research - Department of Medicine

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