A Case of 23-year-old male with CNS toxoplasmosis / [author]: Del Fuerte, Eric Miguel G.

Includes bibliographical references

ABSTRACT: Cerebral toxoplasmosis, caused by the intracellular protozoan parasite Toxoplasma gondii, poses a significant threat to individuals with compromised immune systems, especially those living with HIV/AIDS. Despite the advancements in antiretroviral therapy, cerebral toxoplasmosis remains a significant concern for HIV/AIDS patients. We seek to elucidate the impaired antiparasitic T-cell response in immunocompromised patients, which undermines their ability to control the intracellular parasite. By examining the immune response dynamics in patients with cerebral toxoplasmosis, we aim to identify the factors contributing to the reactivation of latent brain cysts and the progression of the disease. By investigating diagnostic biomarkers, imaging techniques, and risk factors associated with the development of cerebral toxoplasmosis, we aim to identify high-risk individuals and implement preventive measures. Early diagnosis and prevention are crucial in reducing the incidence and burden of this infection among HIV/AIDS patients. OBJECTIVES: 1. To comprehensively analyze the case of a 23-year-old immunocompromised male with neurological symptoms, including headache, fever, vomiting, and abdominal pain, to provide a detailed and insightful presentation. 2. To critically evaluate the diagnostic approach for patients who are immunocompromised and presenting with neurologic symptoms, exploring current guidelines and best practices to ensure effective and timely diagnosis. 3. To address the challenges associated with cerebral toxoplasmosis by investigating its pathogenesis, improving treatment outcomes, and developing strategies for early diagnosis and prevention.

Research - Department of Medicine