Basic and clinical pharmacology / edited by Bertram G. Katzung ; associate editor Anthony J. Trevor.

Basic principles. Introduction : the nature of drugs and drug development and regulation / Bertram G. Katzung -- Drug receptors and pharmacodynamics / Mark von Zastrow -- Pharmacokinetics and pharmacodynamics : rational dosing and the time course of drug action / Nicholas H.G. Holford -- Drug biotransformation / Maria Almira Correia -- Pharmacogenomics / Jennifer E. Hibma and Kathleen M. Giacomini -- Autonomic drugs. Introduction to autonomic pharmacology / Bertram G. Katzung -- Cholinoceptor-activating and cholinesterase-inhibiting drugs / Achilles J. Pappano -- Cholinoceptor-blocking drugs / Achilles J. Pappano -- Adrenoceptor agonists and sympathomimetic drugs / Italo Biaggioni and David Robertson -- Adrenoceptro antagonist drugs / David Robertson and Italo Biaggioni -- Cardiovascular-renal drugs. Antihypertensive agents / Neal L. Benowitz -- Vasodilators and the treatment of angina pectoris / Bertram G. Katzung -- Drugs used in heart failure / Bertram G. Katzung -- Agents used in cardiac arrhythmias / Joseph R. Hume and Augustus O. Grant -- Diuretic agents / Ramin Sam, David Pearce and Harlan E. Ives -- Drugs with important actions on smooth muscle. Histamine, serotonin, and the ergot alkaloids / Bertram G. Katzung -- Vasoactive peptides / Ian A. Reid -- The eicosanoids : prostaglandins, thromboxanes, leukotrienes, and related compounds / Emer M. Smyth and Garret A. FitzGerald -- Nitric oxide / Samie R. Jaffrey -- Drugs used in asthma / Joshua M. Galanter and Homer A. Boushey -- Drugs that act in the cental nervous system. Introduction to the pharmacology of CNS drugs / John A. Gray and Roger A. Nicoll -- Sedative-hypnotic drugs / Anthony J. Trevor -- The alcohols / Susan B. Masters and Anthony J. Trevor -- Antiseizure drugs / Roger J. Porter and Brian S. Meldrum -- General anesthetics / Helge Eilers -- Local anesthetics / Kenneth Drasner -- Skeletal muscle relaxants / Marieke Kruidering-Hall and Lundy Campbell -- Pharmocologic management of Parkinsonism and other movement disorders / Michael J. Aminoff - Antipsychotic agents and lithium / Charles DeBattista -- Antidepressant agents / Charles DeBattista -- Opiod agonists and antagonists / Mark A. Schumacher, Allen I. Basbaum, and Ramana K. Naidu -- Drugs of abuse / Christian Lüscher --Drugs used to treat diseases of the blood, inflammation, and gout. Agents used in cytopenias ; Hematopoietic growth factors / James L. Zehnder -- Drugs used in disorders of coagulation / James L. Zehnder -- Agents used in dyslipidemia / Mary J. Malloy and John P. Kane -- Nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, nonopioid analgesics, and drugs used in gout / Nabeel H. Borazan and Daniel E. Furst -- Endocrine drugs. Hypothalamic and pituitary hormones / Roger K. Long and Hakan Cakmak -- Thyroid and antithyroid drugs / Betty J. Dong and Francis S. Greenspan -- Adrenocorticosteroids and adrenocortical antagonists / George P. Chrousos --The gonadal hormones and inhibitors / George P. Chrousos -- Pancreatic hormones and antidiabetic drugs / Martha S. Nolte Kennedy and Umesh Masharani -- Agents that affect bone mineral homeostasis / Daniel D. Bikle -- Chemotherapeutic drugs. Beta-lactam and other cell wall- and membrane-active antibiotics / Daniel H. Deck and Lisa G. Winston -- Tetracyclines, macrolides, clindamycin, chloramphenicol, streptogramins, and oxazolidinones / Daniel H. Deck and Lisa G. Winston -- Aminoglycosides and spectnomycin / Daniel H. Deck and Lisa G. Winston -- Sulfonamides, trimethoprim, and quinolones / Daniel H. Deck and Lisa G. Winston -- Antimycobacterial drugs / Daniel H. Deck and Lisa G. Winston -- Antifungal agents / Don Sheppard and Harry W. Lampiris -- Antiviral agents / Sharon Safrin -- Miscellaneous antimicrobial agents ; disinfectants, antiseptics, and sterilants / Daniel H. Deck and Lisa G. Winston -- Clinical use of antimicrobial agents / Harry W. Lampiris and Daniel S. Maddix -- Antiprotozoal drugs / Philip J. Rosenthal -- Clinical pharmacology of the antihelminthic drugs / Philip J. Rosenthal -- Cancer chemotherapy / Edward Chu and Alan C. Sartorelli -- Immunopharmacology / Douglas F. Lake and Adrienne D. Briggs -- Toxicology. Introduction to toxicology : occupational and environmental / Daniel T. Teitelbaum -- Heavy metal intoxication and chelators / Michael J. Kosnett -- Management of the poisoned patient / Kent R. Olson -- Special topics. Special aspects of perinatal and pediatric pharmacology / Gideon Koren -- Special aspects of geriatric pharmacology / Bertram G. Katzung -- Dermatologic pharmacology / Dirk B. Robertson and Howard I. Maibach -- Drugs used in the treatment of gastrointestianl diseases / Kenneth R. McQuaid -- Therapeutic and toxic potential of over-the-counter agents / Robin L. Corelli -- Dietary supplements and herbal medications / Cathi E. Dennehy and Candy Tsourounis -- Rational prescribing and prescription writing / Paul W. Lofholm and Bertram G. Katzung -- Important drug interactions and their mechanisms / John R. Horn -- Appendix : vaccines, immune globulins, and other complex biologic products / Harry W. Lampiris and Daniel S. Maddix

Includes bibliographical references and index.

Organized to reflect the course sequence in many pharmacology courses and in integrated curricula, Basic and Clinical Pharmacology covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. Selection of the subject matter and order of its presentation are based on the authors` many years of experience in teaching this material to thousands of medical, pharmacy, dental, podiatry, nursing, and other health science students.Coverage that spans every aspect of medical pharmacology, including botanicals and over-the-counter drugs, and pharmacogenomics with examples. Emphasis is placed on discussion of drug groups and prototypes. Includes sections that specifically address the clinical choice and use of drugs in patients and the monitoring of their effects. Case studies introduce clinical problems in most chapters. Summary tables and diagrams encapsulate important information. A generic name/trade name table appears at the end of most chapters for easy reference when writing a chart order or prescription.

Department of Pharmacology