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Hepatitis B screening practices : is HB's antigen and antibody enough? an analysis of hepatitis B profile results performed at FEU-NRMF Medical Center / Benedict E. Valencia and Wilfredo T. Polido, Jr.

Contributor(s): Language: english Publication details: Fairview, Quezon City: Department of Surgery, FEU-NRMF, 2009.Description: tables; (in folder)Content type:
  • text
Media type:
  • unmediated
Carrier type:
  • volume
LOC classification:
  • SUR 2009 0002
Summary: Abstract: To determine the prevalence of hepatitis B surface antigenemia (HBsAg) and the value of a selective serologic screening rule among high risk patients in a single center. Patients who were referred for serological testing against hepatitis B at FEU-NRMF Medical Center from January 2005 up to October 2007 were analyzed. Patients characteristics and results of hepatitis profile were evaluated. The value of HBsAg and HBsAb for hepatitis screening was assessed using likelihood ratio. A total of 398 patients (219males and 179 females) were tested for HBV infection using the Abbott AxSYM System. The median age was 41± 17.65 years. There were 134 (33.7%) patients with hepatitis B exposure and 87 (21.9%) were HBsAg carriers. Twenty-two (25.3%) of the HBsAg carriers were reactive to HBeAg. There were 116 patients with HBs antibody, *4 (72.4%) of whom were due to hepatitis B vaccination. Screening utilizing HBsAg alone yields a sensitivity of 64.9% and a specificity of 100%. The likelihood ratio for negative test with HBsAg alone is 84.9% while the negative predictive value utilizing both HBsAg and anti-HBs is 91.8%. Sixteen of the 134 patients with hepatitis B exposure were non-reactive to HBsAg and anti-HBs. Two of whom have recent infection (reactive to HBclgM). Selective serologic testing maybe ideal for identifying uninfected patients but not in detecting those with hepatitis B exposure. The prevalence of HBS antigenemia was 21.9% however, even in this high prevalence setting, selective hepatitis B screening using both HBsAg and antiHBs is associated with 11.9% incidence of non-reactivity in patients exposed to hepatitis B and should be advised only in carefully selected patients. A thorough hepatitis profile appears to be an effective strategy for detection of hepatitis B in the context of a high risk population.
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Holdings
Item type Current library Call number Status Notes Date due Barcode
Research Far Eastern University - Nicanor Reyes Medical Foundation Research SUR 2009 0002 (Browse shelf(Opens below)) Not For Loan draft R000637
Room Use Far Eastern University - Nicanor Reyes Medical Foundation Research SUR 2009 0002 (Browse shelf(Opens below)) Available R000281

Includes bibliographical references.

Abstract: To determine the prevalence of hepatitis B surface antigenemia (HBsAg) and the value of a selective serologic screening rule among high risk patients in a single center. Patients who were referred for serological testing against hepatitis B at FEU-NRMF Medical Center from January 2005 up to October 2007 were analyzed. Patients characteristics and results of hepatitis profile were evaluated. The value of HBsAg and HBsAb for hepatitis screening was assessed using likelihood ratio. A total of 398 patients (219males and 179 females) were tested for HBV infection using the Abbott AxSYM System. The median age was 41± 17.65 years. There were 134 (33.7%) patients with hepatitis B exposure and 87 (21.9%) were HBsAg carriers. Twenty-two (25.3%) of the HBsAg carriers were reactive to HBeAg. There were 116 patients with HBs antibody, *4 (72.4%) of whom were due to hepatitis B vaccination. Screening utilizing HBsAg alone yields a sensitivity of 64.9% and a specificity of 100%. The likelihood ratio for negative test with HBsAg alone is 84.9% while the negative predictive value utilizing both HBsAg and anti-HBs is 91.8%. Sixteen of the 134 patients with hepatitis B exposure were non-reactive to HBsAg and anti-HBs. Two of whom have recent infection (reactive to HBclgM). Selective serologic testing maybe ideal for identifying uninfected patients but not in detecting those with hepatitis B exposure. The prevalence of HBS antigenemia was 21.9% however, even in this high prevalence setting, selective hepatitis B screening using both HBsAg and antiHBs is associated with 11.9% incidence of non-reactivity in patients exposed to hepatitis B and should be advised only in carefully selected patients. A thorough hepatitis profile appears to be an effective strategy for detection of hepatitis B in the context of a high risk population.

Research - Department of Surgery

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