Commonly Uncommon: A Case Report of Two Patients with Smooth Muscle Tumor of Uncertain Malignant Potential

Medicine Research project

Uterine Smooth muscle tumors are the most female genital tract neoplasms and are classified into three groups: leiomyomas, leiomyosarcomas and STUMP. Smooth muscle tumors of uncertain malignant potential (STUMP) are mesenchymal uterine tumors lying between benign leiomyosarcomas and is defined by the World Health Organization as uterine smooth muscle tumors that cannot be histologically diagnosed as unequivocally benign or malignant. (7) Most are diagnosed histologically only after woman has undergone surgery for management of leiomyomas and its diagnosis is appropriate when a tumor shows any unusual combination of cytologicatypia, mitotic rate, presence or absence of tumor cell necrosis but does not satisfy the Stanford for Criteria for leiomyosarcomas. This in tun is highly user dependent based on a Pathologist`s eye experience; making its diagnosis a challenge.