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"Small but terrible" : a rare case of olfactory neuroblastoma successfully treated by chemotherapy / Lorelie Ann C. Rivera.

By: Language: English Publication details: Fairview, Quezon City Department of Medicine, FEU-NRMF, 2015Description: photos (colored); (in folder)Content type:
  • text
Media type:
  • unmediated
Carrier type:
  • volume
LOC classification:
  • MED20150004
Summary: ABSTRACT: We report a rare case of olfactory neuroblastoma in a 23 year old female who presented with 3 month history of recurrent nasal congestion associated with intermittent headache, unilateral epistaxis and proptosis of left eye. Cranial MRI with contrast showed a large enhancing sinonasal and anterior skull base mass measuring 6.9x6.3x6.1 cm. Enlarged lymph nodes, right high jugular region and both lateral retropharyngeal spaces. Nasal endoscopy with biopsy revealed fibrocollagenous tissue composed of round cells arranged in sheets, cords and clusters some are separated by thin fibrous tissue. The cells have mild pleomorphism, granular chromatin pattern and scant cytoplasm. With areas of necrosis, congestion and hemorrhage. The findings are consistent with olfactory neuroblastoma. Immunohistochemical staining for Synaptophysin revealed positive, diffuse and strong cytoplasmic expression in neoplastic cells. Chromogranin revealed negative expression in neoplastic cells.
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Research Far Eastern University - Nicanor Reyes Medical Foundation Research MED20150004 (Browse shelf(Opens below)) Available R000455

Includes bibliographical references.

ABSTRACT: We report a rare case of olfactory neuroblastoma in a 23 year old female who presented with 3 month history of recurrent nasal congestion associated with intermittent headache, unilateral epistaxis and proptosis of left eye. Cranial MRI with contrast showed a large enhancing sinonasal and anterior skull base mass measuring 6.9x6.3x6.1 cm. Enlarged lymph nodes, right high jugular region and both lateral retropharyngeal spaces. Nasal endoscopy with biopsy revealed fibrocollagenous tissue composed of round cells arranged in sheets, cords and clusters some are separated by thin fibrous tissue. The cells have mild pleomorphism, granular chromatin pattern and scant cytoplasm. With areas of necrosis, congestion and hemorrhage. The findings are consistent with olfactory neuroblastoma. Immunohistochemical staining for Synaptophysin revealed positive, diffuse and strong cytoplasmic expression in neoplastic cells. Chromogranin revealed negative expression in neoplastic cells.

Research - Department of Medicine

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