A COMPARATIVE STUDY OF THE ANTI-PYRETIC EFFECTS OF THE CRUDE EXTRACT OF PORTULACA OLERACEA (GULASIMAN) WITH AN ESTABLISHED ANTIPYRETIC DRUG, PARACETAMOL (TEMPRA), TO FEVER-INDUCED RABBITS.
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Item type | Current library | Call number | Status | Date due | Barcode | |
---|---|---|---|---|---|---|
Theses | Far Eastern University - Nicanor Reyes Medical Foundation Theses | MPHARND0016c.1 (Browse shelf(Opens below)) | Available | T000916 | ||
Theses | Far Eastern University - Nicanor Reyes Medical Foundation Theses | MPHARND0016c.2 (Browse shelf(Opens below)) | Available | T000917 |
Pharmacology Thesis
Portulaca oleracea (Gulasiman) extract, which showed antipyretic effects from a previous experiment, was tested at different dose levels (158.5 mg/kg BW, 630.9 mg/kg BW, and 2511 mg/kg BW) to fever-induced rabbits to determine the concentration that is closest to the antipyretic effect obtained from a commercial drug, Paracetamol (Tempra) The study showed that a dose of 158.5 mg/kg BW had no significant anti-pyretic effects, while significant anti-pyretic effects were noted at doses of 630.9 mg/kg BW and 2511 mg/kg BW. The latter shows the value closest to that of Paracetamol (Tempra) Although all dose levels showed anti-pyretic effects, statistical analysis revealed that Tempra had a greater fever-reducing effect than Portulaca oleracea. Statistical significance was confirmed using ANOVA.
Department of Pharmacology
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