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THE EXPERIMENTAL STUDY ON THE EFFICACY OF THE FRUIT EXTRACT OF CAPSICUM FRUTESCENS (SILING LABUYO) AS A TOPICAL AGENT IN RABBITS

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  • THE M-PHAR ND 0035
Dissertation note: Pharmacology Thesis Summary: Three different concentrations with Capsicum frutescens extract were prepared as dilution of 0.25; 0.50 and 0.75. Using coconut oil as the diluent, their anesthetic effect was measured using the skin twitch response. Two parameters were observed, the onset of action, which is the time when the skin twitch response disappeared, and the duration of action, which is the time from the onset up to the recurrence of the skin twitch response. Comparison of the different concentration of "siling labuyo" extracts relative to the negative control (coconut only) was eventually done to determine the concentration that exhibited an onset and duration of action comparable to that of the positive control (topical lidocaine). The results were analyzed using statistical method via Fisher`s extract and Chi-square determination. Among the different concentrations of the fruit extract, the concentration of 0.75 of capsaicin showed an anesthetic duration comparable to that of Lidocaine.
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Holdings
Item type Current library Call number Status Date due Barcode
Theses Far Eastern University - Nicanor Reyes Medical Foundation Theses MPHARND0035c.1 (Browse shelf(Opens below)) Available T000945
Theses Far Eastern University - Nicanor Reyes Medical Foundation Theses MPHARND0035c.2 (Browse shelf(Opens below)) Available T000946

Pharmacology Thesis

Three different concentrations with Capsicum frutescens extract were prepared as dilution of 0.25; 0.50 and 0.75. Using coconut oil as the diluent, their anesthetic effect was measured using the skin twitch response. Two parameters were observed, the onset of action, which is the time when the skin twitch response disappeared, and the duration of action, which is the time from the onset up to the recurrence of the skin twitch response. Comparison of the different concentration of "siling labuyo" extracts relative to the negative control (coconut only) was eventually done to determine the concentration that exhibited an onset and duration of action comparable to that of the positive control (topical lidocaine). The results were analyzed using statistical method via Fisher`s extract and Chi-square determination. Among the different concentrations of the fruit extract, the concentration of 0.75 of capsaicin showed an anesthetic duration comparable to that of Lidocaine.

Department of Pharmacology

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