A STUDY ON THE ANESTHETIC AND SEDATIVE-HYPNOTIC EFFECT OF THE ROOTS OF JASMINUM SAMBAC, LINN (OLEACEAE)

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Language: English Publication details: QUEZON CITY FEU-NRMF NDDescription: 16 PAGESLOC classification:

MPHARND0041

Summary: ABSTRACT: This study seeks to investigate the anesthetic and sedative-hypnotic properties of the roots of Jasminum samba. Extraction of the plant material was performed by cold percolation method using methanol as solvent. Healthy and randomly selected Swiss mice were administered with 0.2 % extract, standard drugs (Lidocaine, Phenobarbital), negative control (Normal Saline Solution). In this study, two parameters were used to test the efficiency of the extract - the Bier Block-Tail Clamping Method for the determination of the local anesthetic effect using Lidocaine as the standard drug, test for sleeping inducing potential using Phenential using Phenobarbital. The results of the extract were compared to the standard drugs and there were no significant difference between the response obtained for Lidocaine and the crude extract in terms of anesthetic properties using the Bier Block-Tail Clamping Method and the results from Phenobarbital and the crude extract in terms of sedative-hypnotic effect using sleep induction time.

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Holdings
Item type	Current library	Call number	Status	Date due	Barcode
Theses	Far Eastern University - Nicanor Reyes Medical Foundation Theses	MPHARND0041C.1 (Browse shelf(Opens below))	Available		T000954
Theses	Far Eastern University - Nicanor Reyes Medical Foundation Theses	MPHARND0041C.2 (Browse shelf(Opens below))	Available		T000955

ABSTRACT: This study seeks to investigate the anesthetic and sedative-hypnotic properties of the roots of Jasminum samba. Extraction of the plant material was performed by cold percolation method using methanol as solvent. Healthy and randomly selected Swiss mice were administered with 0.2 % extract, standard drugs (Lidocaine, Phenobarbital), negative control (Normal Saline Solution). In this study, two parameters were used to test the efficiency of the extract - the Bier Block-Tail Clamping Method for the determination of the local anesthetic effect using Lidocaine as the standard drug, test for sleeping inducing potential using Phenential using Phenobarbital. The results of the extract were compared to the standard drugs and there were no significant difference between the response obtained for Lidocaine and the crude extract in terms of anesthetic properties using the Bier Block-Tail Clamping Method and the results from Phenobarbital and the crude extract in terms of sedative-hypnotic effect using sleep induction time.

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