COMPARATIVE STUDY ON THE EFFECTS OF TOPICALLY ADMINISTERED ACETAZOLAMIDE WITH 0.9% NSS AND TOPICAL ACETAZOLAMIDE IN HPM IN THE INTRAOCULAR PRESSURE OF ALBINO RABBITS

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Publication details: QUEZON CITY FEU-NRMF March 2000LOC classification:

MPHAR20000010

Summary: ABSTRACT: Hydroxypropyl methylcellulose, a known opthalmic solution vehicle, is combined with acetazolamide, an accepted intraocular lowering agent, to make a 0.8% solution and instilled into the conjunctival cul-de-sac of rabbit`s eyes. Topical administration of the 0.8% acetazolamide - HPM solution after the oral induction of water resulted to a slow but sustained in the artificially induced rise in the intraocular pressure of rabbit`s eyes after 30, 60, and 120 minutes following waterloading in comparison to eyes treated with acetazolamide in 0.9% NSS . In the eyes treated with 0.9% acetazolamide - NSS, the decrease in intraocular pressure was found to be immediate but short in duration when measured after 30, 60, and 120 minutes. No conjunctival nor corneal irritation as well as any observable side effects were noted.

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Item type	Current library	Call number	Status	Date due	Barcode
Theses	Far Eastern University - Nicanor Reyes Medical Foundation Theses	MPHAR20000010C.1 (Browse shelf(Opens below))	Available		T000842
Theses	Far Eastern University - Nicanor Reyes Medical Foundation Theses	MPHAR20000010C.2 (Browse shelf(Opens below))	Available		T000843

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ABSTRACT: Hydroxypropyl methylcellulose, a known opthalmic solution vehicle, is combined with acetazolamide, an accepted intraocular lowering agent, to make a 0.8% solution and instilled into the conjunctival cul-de-sac of rabbit`s eyes. Topical administration of the 0.8% acetazolamide - HPM solution after the oral induction of water resulted to a slow but sustained in the artificially induced rise in the intraocular pressure of rabbit`s eyes after 30, 60, and 120 minutes following waterloading in comparison to eyes treated with acetazolamide in 0.9% NSS . In the eyes treated with 0.9% acetazolamide - NSS, the decrease in intraocular pressure was found to be immediate but short in duration when measured after 30, 60, and 120 minutes. No conjunctival nor corneal irritation as well as any observable side effects were noted.

Department of Pharmacology

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