"REDUCTION OF CARRAGEENAN-INDUCED RAT PAW EDEMA BY TOPICALLY APPLIED SAMPALOC PULP (TAMARINDUS INDICA, LINNE) CREAM"

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Language: English Publication details: QUEZON CITY FEU-NRMF MARCH 2003Description: 12 PAGESLOC classification:

MPHAR20030008

Summary: ABSTRACT: This study dealt with the anti-inflammatory activity of the Tamarindus indica commonly known as tamarind. The objectives are (1) to determine the percent reducing capacity of the different tamarind extract concentration (25%, 50%, 75%) on the Carageenan induced rat paw edema; (2) to determine the tamarind extract concentration with the maximum efficacy in reducing edema (3) to determine the concentration with the longest duration of action in reducing edema. 1 kilogram of tamarind fruit pulp was subjected to extraction process, which yielded thirty (30) grams of semi-solid extract. The extract was then subjected to an organic test to determine the presence of tartaric acid. Positive result was obtained. Thirty (30) adult rats with equal proportions of male and female having average weight of 120-240 were randomly grouped into five (6 rats per group) and were injected with Carageenan (1% in NSS) at the left hind paw to induce edema. Rats in group A, positive control were topically applied with 1% Aplosyn; Group B the negative control were applied with White Petrolatum and Groups C, D, E the test group were applied with Tamarind extracts (25%, 50% and 75% respectively). Percentage edema reduction was tetermined 1 and 2 hours after the induction of each agent. Results showed that 25% tamarind extract caused 24.208% edema reduction, which was the highest percentage edema reduction, obtained after one hour. This was followed by the 75% concentration and lastly by 50% concentration with 19.305% and 15.650% edema reduction. Respectively. Two hours after, 75% tamarind extract showed a continous edema reduction activity (35.966%) while the 25% tamarind extract exhibitd a decreasing activity. Statistical test (ANOVA) showed that the variation of effects of different tamarind extract concentrations on reducing edema is insignificant in both the 1st and 2nd hour since the f ratios obtained in the first and second hour (1.566 and .731 respectively) were less than that of the critical level 3.68. This indicates that percentage edema reduction of tamarind extract is not a function of its concentration.

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Theses	Far Eastern University - Nicanor Reyes Medical Foundation Theses	MPHAR20030008c.2 (Browse shelf(Opens below))	Available		T001746
Theses	Far Eastern University - Nicanor Reyes Medical Foundation Theses	MPHAR20030008 (Browse shelf(Opens below))	Available		T000805

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ABSTRACT: This study dealt with the anti-inflammatory activity of the Tamarindus indica commonly known as tamarind. The objectives are (1) to determine the percent reducing capacity of the different tamarind extract concentration (25%, 50%, 75%) on the Carageenan induced rat paw edema; (2) to determine the tamarind extract concentration with the maximum efficacy in reducing edema (3) to determine the concentration with the longest duration of action in reducing edema. 1 kilogram of tamarind fruit pulp was subjected to extraction process, which yielded thirty (30) grams of semi-solid extract. The extract was then subjected to an organic test to determine the presence of tartaric acid. Positive result was obtained. Thirty (30) adult rats with equal proportions of male and female having average weight of 120-240 were randomly grouped into five (6 rats per group) and were injected with Carageenan (1% in NSS) at the left hind paw to induce edema. Rats in group A, positive control were topically applied with 1% Aplosyn; Group B the negative control were applied with White Petrolatum and Groups C, D, E the test group were applied with Tamarind extracts (25%, 50% and 75% respectively). Percentage edema reduction was tetermined 1 and 2 hours after the induction of each agent. Results showed that 25% tamarind extract caused 24.208% edema reduction, which was the highest percentage edema reduction, obtained after one hour. This was followed by the 75% concentration and lastly by 50% concentration with 19.305% and 15.650% edema reduction. Respectively. Two hours after, 75% tamarind extract showed a continous edema reduction activity (35.966%) while the 25% tamarind extract exhibitd a decreasing activity. Statistical test (ANOVA) showed that the variation of effects of different tamarind extract concentrations on reducing edema is insignificant in both the 1st and 2nd hour since the f ratios obtained in the first and second hour (1.566 and .731 respectively) were less than that of the critical level 3.68. This indicates that percentage edema reduction of tamarind extract is not a function of its concentration.

Department of Pharmacology

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