STUDY ON THE SERUM URIC ACID LOWERING EFFECTS OF MANGIFERA INDICA (MANGO) METHANOLIC EXOCARP EXTRACT AND ALLOPURINOL ON MALE SPRAGUE-DAWLEY RATS

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Publication details: QUEZON CITY FEU-NRMF 2013Description: 26 PAGESLOC classification:

MPHAR20130007

Summary: ABSTRACT: This is a comparative study on the activity of Methanolic Mango exocarp extract and Allopurinol in lowering the uric acid levels of the hyperuricemia-induced male Sprague-Dawley rats. The Sprague-Dawley rats were induced using potassium oxonate into a hyperuricemic state. Subsequently, Allopurinol was introduced to the positive control group and normal saline solution (NSS) to the negative control group. A non-parametric test was used in comparing the difference of uric acid level before and after injection of the solution to the subjects. The uric acid lowering activity of methnolic mango extract is greater than that of Allopurinol in hyperuricemia-induced Sprague-Dawley rats. However, the study did not cover the substance analysis, toxicity, and the therapeutic ranges of the test substances. Therefore, we recommend further studies on the onset and duration of serum uric acid lowering action of mango exocarp extract.

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Item type	Current library	Call number	Status	Barcode
Theses	Far Eastern University - Nicanor Reyes Medical Foundation Theses	MPHAR20130007C.1 (Browse shelf(Opens below))	Available	T001028
Theses	Far Eastern University - Nicanor Reyes Medical Foundation Theses	MPHAR20130007C.2 (Browse shelf(Opens below))	Available	T001029
Theses	Far Eastern University - Nicanor Reyes Medical Foundation Theses	MPHAR20130007C.3 (Browse shelf(Opens below))	Available	T001030

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Previous	MPHAR20130006C.1 A STUDY ON THE POTENTIATING EFFECT OF THE DECOCTION OF MORINGA OLEIFERA (MALUNGGAY) LEAF ON THE SEDATIVE ACTIVITY OF DIAZEPAM ON MALE SPRAGUE DAWLEY RATS	MPHAR20130006C.2 A STUDY ON THE POTENTIATING EFFECT OF THE DECOCTION OF MORINGA OLEIFERA (MALUNGGAY) LEAF ON THE SEDATIVE ACTIVITY OF DIAZEPAM ON MALE SPRAGUE DAWLEY RATS	MPHAR20130006C.3 A STUDY ON THE POTENTIATING EFFECT OF THE DECOCTION OF MORINGA OLEIFERA (MALUNGGAY) LEAF ON THE SEDATIVE ACTIVITY OF DIAZEPAM ON MALE SPRAGUE DAWLEY RATS	MPHAR20130007C.1 STUDY ON THE SERUM URIC ACID LOWERING EFFECTS OF MANGIFERA INDICA (MANGO) METHANOLIC EXOCARP EXTRACT AND ALLOPURINOL ON MALE SPRAGUE-DAWLEY RATS	MPHAR20130007C.2 STUDY ON THE SERUM URIC ACID LOWERING EFFECTS OF MANGIFERA INDICA (MANGO) METHANOLIC EXOCARP EXTRACT AND ALLOPURINOL ON MALE SPRAGUE-DAWLEY RATS	MPHAR20130007C.3 STUDY ON THE SERUM URIC ACID LOWERING EFFECTS OF MANGIFERA INDICA (MANGO) METHANOLIC EXOCARP EXTRACT AND ALLOPURINOL ON MALE SPRAGUE-DAWLEY RATS	MPHAR20140001C.1 DETERMINATION OF THE MEDIAN LETHAL DOSE AND ACUTE TOXICITIES OF ANGELICA KEISKEI CRUDE EXTRACT	Next

ABSTRACT: This is a comparative study on the activity of Methanolic Mango exocarp extract and Allopurinol in lowering the uric acid levels of the hyperuricemia-induced male Sprague-Dawley rats. The Sprague-Dawley rats were induced using potassium oxonate into a hyperuricemic state. Subsequently, Allopurinol was introduced to the positive control group and normal saline solution (NSS) to the negative control group. A non-parametric test was used in comparing the difference of uric acid level before and after injection of the solution to the subjects. The uric acid lowering activity of methnolic mango extract is greater than that of Allopurinol in hyperuricemia-induced Sprague-Dawley rats. However, the study did not cover the substance analysis, toxicity, and the therapeutic ranges of the test substances. Therefore, we recommend further studies on the onset and duration of serum uric acid lowering action of mango exocarp extract.

Department of Pharmacology

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