A Comprehensive review of topical drugs loaded in nanostructed lipid carriers and its effect on skin permeation rate / Kurt Jan M. Amor, Kristoff Antonilde R. Avehuro, Christian Benedict V. Barrozo, Cloyd Red B. Bondoc and Jonalyn Joyce V. Carpio.

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Language: english Publication details: Fairview, Quezon City: School of Pharmacy, FEU-NRMF, 2017.Description: 57 pages: tables, photos; 28 cm. + CD (soft copy)Content type:

text

Media type:

unmediated

Carrier type:

volume

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LOC classification:

PH 2017 0002

Summary: Abstract: Nanostructured Lipid Carrier (NLC) is a drug carrier system in which the drug is loaded into a blend of solid and liquid lipids. This entrapment of drug inside a Nano-sized lipid matrix increases its stability, bioavailability, and efficacy. The goal of the research is to further learn about NLC as a carrier system for specific administration route. Selected drugs for topical administration to analyze because topical drugs tend to have a problem with barrier function of the skin which limits the drug penetration. Selection of the studies which were included depended on the information it gives about NLC. Excluded were the ones which did not focus on NLC and ones that gives no information about NLC. The data that was used was selected by looking at the drug permeation results of different studies using ProQuest, Sciencedirect and Researchgate using the following term such as Nanostructured Lipid Carrier, skin permeation rate of NLC, and topical application of NLC. The data showed that 22 out of 24 drugs have an increased skin permeation rate. The two drugs that showed no significant increase in skin permeation rate was Celecoxib and Miconazole.

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Holdings
Item type	Current library	Call number	Status	Notes	Date due	Barcode
Room Use	Far Eastern University - Nicanor Reyes Medical Foundation Theses	PH 2017 0002 (Browse shelf(Opens below))	Available	with CD (soft copy)		T001833

Includes appendices and bibliographical references.

Abstract: Nanostructured Lipid Carrier (NLC) is a drug carrier system in which the drug is loaded into a blend of solid and liquid lipids. This entrapment of drug inside a Nano-sized lipid matrix increases its stability, bioavailability, and efficacy. The goal of the research is to further learn about NLC as a carrier system for specific administration route. Selected drugs for topical administration to analyze because topical drugs tend to have a problem with barrier function of the skin which limits the drug penetration. Selection of the studies which were included depended on the information it gives about NLC. Excluded were the ones which did not focus on NLC and ones that gives no information about NLC. The data that was used was selected by looking at the drug permeation results of different studies using ProQuest, Sciencedirect and Researchgate using the following term such as Nanostructured Lipid Carrier, skin permeation rate of NLC, and topical application of NLC. The data showed that 22 out of 24 drugs have an increased skin permeation rate. The two drugs that showed no significant increase in skin permeation rate was Celecoxib and Miconazole.

Thesis - School of Pharmacy

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