Antiangiogenic activity of methanolic extract of lagerstroemia speciosa leaves using chick chorioallantoic membrane (CAM) essay / Yaella Rei A. Aurelio, Erika Rose N. Bacaro, Karen Mae D. Becares and Sandra T. Belen.

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Language: english Publication details: Fairview, Quezon City: School of Pharmacy, FEU-NRMF, 2017.Description: 67 pages: illustrations, tables, photos; 28 cm. + CD (soft copy)Content type:

text

Media type:

unmediated

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volume

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LOC classification:

PH 2017 0007

Summary: Abstract: Angiogenesis is the growth of new capillaries from existing blood vessels. It is mediated by a complex multistep comprising a series of cellular events that lead to neovascularisation. It was proposed nearly 45 years ago, that by blocking tumor angiogenesis can help treat cancer. Decades of experimental evidence have shown that solid tumor growth is dependent on angiogenic formation of new blood vessels - making it a therapeutic option. This study aims to test the antiangiogenic property of methanolic extract of Lagerstroemia speciosa L. (also known as Banaba in the Philippines) using CAM assay. This study will determine and compare the antiangiogenic property of methanolic crude extract of L. speciosa injected in a day 8 old chick embryo egg in different extract concentrations (5µg/ml, 10µg/ml, 20µg/ml) and divided into 5 groups : methotrexate (positive control), distilled water (negative control), and the succeeding groups with different concentrations. Based on the results, the higher the concentration of methanolic extract of banaba leaves implanted in CAM generally led to higher level of angiogenesis inhibition. Therefore, the researchers conclude that the ectracts of L. speciosa leaves have anti-angiogenic property.

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Holdings
Item type	Current library	Call number	Status	Notes	Date due	Barcode
Room Use	Far Eastern University - Nicanor Reyes Medical Foundation Theses	PH 2017 0007 (Browse shelf(Opens below))	Available	with CD (soft copy)		T001838

Includes appendices and bibliographical references.

Abstract: Angiogenesis is the growth of new capillaries from existing blood vessels. It is mediated by a complex multistep comprising a series of cellular events that lead to neovascularisation. It was proposed nearly 45 years ago, that by blocking tumor angiogenesis can help treat cancer. Decades of experimental evidence have shown that solid tumor growth is dependent on angiogenic formation of new blood vessels - making it a therapeutic option. This study aims to test the antiangiogenic property of methanolic extract of Lagerstroemia speciosa L. (also known as Banaba in the Philippines) using CAM assay. This study will determine and compare the antiangiogenic property of methanolic crude extract of L. speciosa injected in a day 8 old chick embryo egg in different extract concentrations (5µg/ml, 10µg/ml, 20µg/ml) and divided into 5 groups : methotrexate (positive control), distilled water (negative control), and the succeeding groups with different concentrations. Based on the results, the higher the concentration of methanolic extract of banaba leaves implanted in CAM generally led to higher level of angiogenesis inhibition. Therefore, the researchers conclude that the ectracts of L. speciosa leaves have anti-angiogenic property.

Thesis - School of Pharmacy

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