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A STUDY ON THE ANTI-INFLAMMATORY ACTIVITY OF VETIVERIA ZIZANIOIDES LINNE. (GRAMINAE)

By: Contributor(s): Language: English Producer: 2001Description: NO NO. OF PAGESContent type:
  • Text
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  • Unmediated
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LOC classification:
  • THE M-PHAR 2001 0010
Dissertation note: Pharmacology Thesis Summary: The extraction of Vetiveria zizanioides was done using maceration and percolation method. Eighty percent (80%) of ethanol was used as a solvent to provide enough water to the dried plant. Determination of the Approximate Lethal Dose (ALD) followed. Working with only five different doses starting from 500 mg/kg Body Weight and an increasing interval of 500 mg/kg Body Weight and injecting to the five groups of guinea pigs, in which each of the group has one male and one female, the approximate lethal dose of Vetiveria zizanioides was found to be 1500 mg/kg Body Weight in a concentration of 30 g/100 mL. The pharmacological testing for anti-inflammatory drug was done using 10 guinea pigs, five for the experimental drug and five for the positive control, which is Mefenamic acid (Ponstan). Inflammation was induced using carrageenan-induced rat paw edema method and anti-inflammatory property of the drug was measured using the plethysmometer apparatus. The extract showed a good anti-inflammatory effect activity comparing with the positive control, Mefenamic Acid 6.5 mg/kg Body Weight (Ponstan Suspension 50 mg/5 mL).
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Item type Current library Call number Status Date due Barcode
Theses Far Eastern University - Nicanor Reyes Medical Foundation Theses MPHAR20010010c.1 (Browse shelf(Opens below)) Available T000784
Theses Far Eastern University - Nicanor Reyes Medical Foundation Theses MPHAR20010010c.2 (Browse shelf(Opens below)) Available T000870

Pharmacology Thesis

The extraction of Vetiveria zizanioides was done using maceration and percolation method. Eighty percent (80%) of ethanol was used as a solvent to provide enough water to the dried plant. Determination of the Approximate Lethal Dose (ALD) followed. Working with only five different doses starting from 500 mg/kg Body Weight and an increasing interval of 500 mg/kg Body Weight and injecting to the five groups of guinea pigs, in which each of the group has one male and one female, the approximate lethal dose of Vetiveria zizanioides was found to be 1500 mg/kg Body Weight in a concentration of 30 g/100 mL. The pharmacological testing for anti-inflammatory drug was done using 10 guinea pigs, five for the experimental drug and five for the positive control, which is Mefenamic acid (Ponstan). Inflammation was induced using carrageenan-induced rat paw edema method and anti-inflammatory property of the drug was measured using the plethysmometer apparatus. The extract showed a good anti-inflammatory effect activity comparing with the positive control, Mefenamic Acid 6.5 mg/kg Body Weight (Ponstan Suspension 50 mg/5 mL).

Department of Pharmacology

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