The Effect of lycopene from lycopene capsule (lyc-O-mato) on isoniazid-induced seizure in imprinting controlled region (ICR) mice / Section E2; Dennis Ivan Bravo.

Contributor(s):

Language: english Publication details: Fairview, Quezon City: Department of Biochemistry, FEU-NRMF, 2012.Description: 70 pages: illustrations tables, photos; 28 cmContent type:

text

Media type:

unmediated

Carrier type:

volume

LOC classification:

M BIO 2012 0004

Summary: Abstract: Antioxidanta have been linked with anticonvulsnt properties. Lycopene is a well known compound that has antioxidant property and is popularly found in tomatoes. This study aims to determine effect of lycopene from lycopene capsule (Lyc-O-Mato) on the duration of isoniazid-induced seizures in ICR mice as an alternatve therapy to commercially available anti-seizure drug. Fourty-three (43) mice of either sex were grouped according to their respective treatments as follows: diazepan 10 mg/kg, lycopene concentrate of 20mg/kg and a negative control group. After which, they were subjected to isoniazid-induced seizure. Seizure activity was video recorded and graded using the Revised Racine`s Scale. P-values of <0.05 indicate significant differences. Statistical analyses used are One-Way ANOVA, with Duncan`s Multiple Range Test (DMRT), Kruskal - Wallis Analysis of Variance, with Student-Newman-Keuls (S-N-K) test for post hoc analysis and Fisher`s exact test. Results showed that the average duration of all the groups are the same. On the countrary, lycopene of any dosage or diazepam mostly manifested motionless staring compared to the control. Therefore, lycopene from lycopene capsule did not have a very significant effect on isoniazid-induce seizure activity of ICR mice.

Average rating: 0.0 (0 votes)

Holdings
Item type	Current library	Call number	Status	Date due	Barcode
Room Use	Far Eastern University - Nicanor Reyes Medical Foundation Theses	M BIO 2012 0004 (Browse shelf(Opens below))	Available		T000735

Includes appendices and bibliographical references.

Abstract: Antioxidanta have been linked with anticonvulsnt properties. Lycopene is a well known compound that has antioxidant property and is popularly found in tomatoes. This study aims to determine effect of lycopene from lycopene capsule (Lyc-O-Mato) on the duration of isoniazid-induced seizures in ICR mice as an alternatve therapy to commercially available anti-seizure drug. Fourty-three (43) mice of either sex were grouped according to their respective treatments as follows: diazepan 10 mg/kg, lycopene concentrate of 20mg/kg and a negative control group. After which, they were subjected to isoniazid-induced seizure. Seizure activity was video recorded and graded using the Revised Racine`s Scale. P-values of <0.05 indicate significant differences. Statistical analyses used are One-Way ANOVA, with Duncan`s Multiple Range Test (DMRT), Kruskal - Wallis Analysis of Variance, with Student-Newman-Keuls (S-N-K) test for post hoc analysis and Fisher`s exact test. Results showed that the average duration of all the groups are the same. On the countrary, lycopene of any dosage or diazepam mostly manifested motionless staring compared to the control. Therefore, lycopene from lycopene capsule did not have a very significant effect on isoniazid-induce seizure activity of ICR mice.

Thesis - Department of Biochemistry & Nutrition

There are no comments on this title.

to post a comment.