COMPARATIVE STUDY ON THE EFFECTS OF TOPICALLY ADMINISTERED ACETAZOLAMIDE WITH 0.9% NSS AND TOPICAL ACETAZOLAMIDE IN HPM IN THE INTRAOCULAR PRESSURE OF ALBINO RABBITS
Publication details: QUEZON CITY FEU-NRMF March 2000LOC classification:- MPHAR20000010
Item type | Current library | Call number | Status | Date due | Barcode | |
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Theses | Far Eastern University - Nicanor Reyes Medical Foundation Theses | MPHAR20000010C.1 (Browse shelf(Opens below)) | Available | T000842 | ||
Theses | Far Eastern University - Nicanor Reyes Medical Foundation Theses | MPHAR20000010C.2 (Browse shelf(Opens below)) | Available | T000843 |
ABSTRACT: Hydroxypropyl methylcellulose, a known opthalmic solution vehicle, is combined with acetazolamide, an accepted intraocular lowering agent, to make a 0.8% solution and instilled into the conjunctival cul-de-sac of rabbit`s eyes. Topical administration of the 0.8% acetazolamide - HPM solution after the oral induction of water resulted to a slow but sustained in the artificially induced rise in the intraocular pressure of rabbit`s eyes after 30, 60, and 120 minutes following waterloading in comparison to eyes treated with acetazolamide in 0.9% NSS . In the eyes treated with 0.9% acetazolamide - NSS, the decrease in intraocular pressure was found to be immediate but short in duration when measured after 30, 60, and 120 minutes. No conjunctival nor corneal irritation as well as any observable side effects were noted.
Department of Pharmacology
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