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Malignant hyperthermia : a case report / Sara A. Bonoan.

Contributor(s): Language: english Publication details: Fairview, Quezon City: Department of Anesthesiology, FEU-NRMF, 2010.Description: 18 pages: tables; (in folder)Content type:
  • text
Media type:
  • unmediated
Carrier type:
  • volume
Subject(s): LOC classification:
  • ANES 2010 0004
Summary: Abstract; Malignant htperthermia (MH) is a rare pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as isoflurane and depolarizing neuromuscular blocking agent, succinycholine. It is said to be to a defective calcium channel located in the sarcoplasmic reticulum membrane called the ryanodine receptor.\ Presented is a case of a 55 year old male who underwent direct laryngoscopy under general anesthesia in which the classic signs of MH were observed such as hyperthermia to a marked degree, tachycardia, tachypnea, increased end-tidal carbon-dioxide, acidosis, muscle rigidity and rhaabdomyolysis. These pathophysiologic changes of MH could lead to life-threatening complications like renal failure from rhabdomyolysis and disseminated intravascular coagulation (DIC) which were seen in our patient, hence the demise despite resuscitative measures and treatment.
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Item type Current library Call number Status Date due Barcode
Room Use Far Eastern University - Nicanor Reyes Medical Foundation Research ANES 2010 0004 (Browse shelf(Opens below)) Available R000019

Includes appendices and bibliographical references.

Abstract; Malignant htperthermia (MH) is a rare pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as isoflurane and depolarizing neuromuscular blocking agent, succinycholine. It is said to be to a defective calcium channel located in the sarcoplasmic reticulum membrane called the ryanodine receptor.\ Presented is a case of a 55 year old male who underwent direct laryngoscopy under general anesthesia in which the classic signs of MH were observed such as hyperthermia to a marked degree, tachycardia, tachypnea, increased end-tidal carbon-dioxide, acidosis, muscle rigidity and rhaabdomyolysis. These pathophysiologic changes of MH could lead to life-threatening complications like renal failure from rhabdomyolysis and disseminated intravascular coagulation (DIC) which were seen in our patient, hence the demise despite resuscitative measures and treatment.

Research - Department of Anesthesiology

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