Catastrophic antiphospholipid antibody syndrome in a 36-year old female with systemic lupus erythematosus / Maria Frances Noreen C. De Leon.

By:

De Leon, Maria Frances Noreen C., MD [author]

Language: English Publication details: Fairview, Quezon City Department of Internal Medicine, FEU-NRMF, 2018Description: photos (black and white); (in folder)Content type:

rdacontent

Media type:

rdamedia

Carrier type:

rdacarrier

LOC classification:

MED20180005

Summary: ABSTRACT: Antiphospholipid syndrome (APS) is a multisystem autoimmune condition characterized by vascular thromboses and/or pregnancy loss associated with persistently positive antiphospholipid antibodies (aPL). Catastrophic APS (CAPS) is the most severe form of APS with multiple organ involvement developing over a short period of time, usually associated with microthromnosis. This is a case of a 36-year old female with history of 2 pregnancy losses, admitted due to right upper quadrant pain and subsequently developed multisytemic organ failure. Patient presented with cerebrovascular infract, pleural effusion, renal failure, heart failure, and psychosis with positive titers for lupus anticoagulant and ANA. Refractory to pulse therapy and anticoagulation, rituximab regimen was then initiated which showed significant improvement in patient's condition.

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Item type	Current library	Call number	Status	Date due	Barcode
Research	Far Eastern University - Nicanor Reyes Medical Foundation Research	MED20180005 (Browse shelf(Opens below))	Available		R000603

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Previous	MED20180002 Percutaneous coronary intervention (PCI) involving left anterior descending artery using retrograde approach /	MED20180003 Emphysematous pyelonephritis class 3b : can it be a conservative or a surgical management? /	MED20180004 "How long can you get?" : a rare case of pancreatic neuroendocrine tumor /	MED20180005 Catastrophic antiphospholipid antibody syndrome in a 36-year old female with systemic lupus erythematosus /	MED20180006 A Case report of coronary artery fistula which drains to the left ventricle /	MED20180007 A Rare case of an extralobar pulmonary sequestration presenting as recurrent pneumonia /	MED20180008 Multiple cranial neuropathy secondary to varicella zoster infection /	Next

Includes bibliographical references.

ABSTRACT: Antiphospholipid syndrome (APS) is a multisystem autoimmune condition characterized by vascular thromboses and/or pregnancy loss associated with persistently positive antiphospholipid antibodies (aPL). Catastrophic APS (CAPS) is the most severe form of APS with multiple organ involvement developing over a short period of time, usually associated with microthromnosis. This is a case of a 36-year old female with history of 2 pregnancy losses, admitted due to right upper quadrant pain and subsequently developed multisytemic organ failure. Patient presented with cerebrovascular infract, pleural effusion, renal failure, heart failure, and psychosis with positive titers for lupus anticoagulant and ANA. Refractory to pulse therapy and anticoagulation, rituximab regimen was then initiated which showed significant improvement in patient's condition.

Research - Department of Medicine

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