A COMPARATIVE STUDY OF THE ADRENERGIC EFFECT OF SYNEPHRINE FROM CALAMANSI (CITRUS MICROCARPA, BUNGE) WASTES AND COMMERCIALLY PREPARED EPINEPHRINE ON ACETYLCHOLINE-INDUCED SMOOTH MUSCLE (UTERUS) ACTIVITY OF ALBINO RATS

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Dissertation note: Pharmacology Thesis Summary: Synephrine, L-p-Hydroxy-a (methylaminomethyl) benzyl alcohol, which was extracted from calamansi (Citrus microcarpa Bunge) waste using the method of Kinoshita was compared with epinephrine, the prototype of adrenergic agents, as to its relaxing effect on the uterine smooth muscle. This study is experimental in nature. The design is used because the experimental material is divided into groups such that the plots making up a particular block are homogenous. The objective of this study is to compare the effect of synephrine from calamansi wastes with the commercially prepared epinephrine using acetylcholine-induced smooth muscle (uterus) contraction of albino rats as parameter. Fifteen (15) uteri of albino rats were used in the study. They were administered with acetylcholine to induce contraction then were divided into 3 groups. Group A served as the control, Group B were given epinephrine and Group C, synephrine. Uterine activity of each rats were recorded using a kymograph machine. The effect of the two agents were compared by using the rate and amplitude of uterine contraction as parameters. Epinephrine yielded a mean amplitude of 12.50mm and a mean rate of 2.6 while synephrine yielded a mean amplitude and rate of 12.71mm and 2.6 respectively. The study revealed that there is no significant difference between synephrine and epinephrine in their relaxing effect on the uterine smooth muscle.

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Theses	Far Eastern University - Nicanor Reyes Medical Foundation Theses	MPHARND0010 (Browse shelf(Opens below))	Available		T000905

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Previous	MPHARND0007 ANTI-CARCINOGENIC AND CYTO-PROTECTIVE PROPERTY OF MORINDA CITRIFOLIA (APATOT) BASED ON THE MICROSCOLONY OF MICE	MPHARN.D.0008 COMPARATIVE EFFECT OF DISTILLED WATER, ORANGE JUICE, AND SODA ON THE ISOLATED DUODENAL SEGMENT OF THE MALE RABBITS	MPHARND0009 THE CONTROLLING EFFECT OF EUGENIA CUMINI LEAVES ON THE ELEVATION OF BLOOD GLUCOSE LEVEL	MPHARND0010 A COMPARATIVE STUDY OF THE ADRENERGIC EFFECT OF SYNEPHRINE FROM CALAMANSI (CITRUS MICROCARPA, BUNGE) WASTES AND COMMERCIALLY PREPARED EPINEPHRINE ON ACETYLCHOLINE-INDUCED SMOOTH MUSCLE (UTERUS) ACTIVITY OF ALBINO RATS	MPHARND0011 A COMPARATIVE STUDY ON THE ANTISEPTIC ACTION OF THE ESSENTIAL OIL OF COLEUS AMBOINICUS (OREGANO) AND PROVIDONE IODINE (BETADINE) ON WOUNDED CAVIA PORCELLUS (GUINEA PIGS) INFECTED WITH STAPHYLOCOCCUS AUREUS	MPHARND0012c.1 A COMPARATIVE STUDY ON THE ANTI-DIARRHEAL EFFECT OF KALANCHOE PINNATA (KATAKA-TAKA) TO THE STANDARD DRUG, DIPHENOXYLATE HCI ATROPINE SULFATE (LOMOTIL)	MPHARND0012c.2 A COMPARATIVE STUDY ON THE ANTI-DIARRHEAL EFFECT OF KALANCHOE PINNATA (KATAKA-TAKA) TO THE STANDARD DRUG, DIPHENOXYLATE HCI ATROPINE SULFATE (LOMOTIL)	Next

Pharmacology Thesis

Synephrine, L-p-Hydroxy-a (methylaminomethyl) benzyl alcohol, which was extracted from calamansi (Citrus microcarpa Bunge) waste using the method of Kinoshita was compared with epinephrine, the prototype of adrenergic agents, as to its relaxing effect on the uterine smooth muscle. This study is experimental in nature. The design is used because the experimental material is divided into groups such that the plots making up a particular block are homogenous. The objective of this study is to compare the effect of synephrine from calamansi wastes with the commercially prepared epinephrine using acetylcholine-induced smooth muscle (uterus) contraction of albino rats as parameter. Fifteen (15) uteri of albino rats were used in the study. They were administered with acetylcholine to induce contraction then were divided into 3 groups. Group A served as the control, Group B were given epinephrine and Group C, synephrine. Uterine activity of each rats were recorded using a kymograph machine. The effect of the two agents were compared by using the rate and amplitude of uterine contraction as parameters. Epinephrine yielded a mean amplitude of 12.50mm and a mean rate of 2.6 while synephrine yielded a mean amplitude and rate of 12.71mm and 2.6 respectively. The study revealed that there is no significant difference between synephrine and epinephrine in their relaxing effect on the uterine smooth muscle.

Department of Pharmacology

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