THE ANTIMUTAGENIC EFFECT OF SWEET POTATO (IPOMOEA BATATAS) ON MITOMYCIN-C INDUCED MALE ALBINO RAT

By:

Bernardo, Bernadette

Contributor(s):

Language: English Producer: 2001Content type:

Text

Media type:

Unmediated

Carrier type:

Volume

LOC classification:

THE M-PHAR 2001 0021

Dissertation note: Pharmacology Thesis Summary: Cancer is one of the fatal diseases known to man. Economic status, culture, genetics and lifestyle are just some of the multifactorial contributors that come into play in the causation of the disease. Seeing the need for cheap and alternative or adjunct to current therapy, this study aims to demonstrate the antimutagenic effect of Ipomoea batatas (kamote) on Mitomycin-C-induced tats. In the experiment, 15 male albino rats were divided into 3 groups with 5 rats each After a week of acclimatization, Group 1 as the baseline negative was given NSS only, Group 2 was given Mitomycin-CC, and Group 3 was given Mitomycin-C and kamote extract After 3 days, the animals were sacrificed. The femurs were isolated and the bone marrow aspirated through syringe. The aspirate was smeared, air dried, stained, and then viewed under compound light microscope. The number of micronuclei was counted per 1,000 rbcs/slide as a measures of mutagenic effect. The values obtained were averaged and analyzed using Analysis of Variance (ANOVA) at F-distribution and Scheffe`s test with a confidence interval of 95%. The result showed that was a significant different between the three groups. There was a significant difference between the frequency of micronuclei in the rbc`s of the group of rats induced with Mitomycin-C and then given kamote extract than those of the group of rats from which kamote extract was witheld, with group 3 mice showing considerably less micronuclei. With the defined parameters for antimutagenicity, plus the demonstrated decrease in micronuclei count in group 3 rats, the researchers concluded the kamote extract as antimutagenic in Mitomycin-C-induced rats.

Average rating: 0.0 (0 votes)

Holdings
Item type	Current library	Call number	Status	Date due	Barcode
Theses	Far Eastern University - Nicanor Reyes Medical Foundation Theses	MPHAR20010021c.1 (Browse shelf(Opens below))	Available		T000897
Theses	Far Eastern University - Nicanor Reyes Medical Foundation Theses	MPHAR20010021c.2 (Browse shelf(Opens below))	Available		T000898

Browsing Far Eastern University - Nicanor Reyes Medical Foundation shelves, Shelving location: Theses Close shelf browser (Hides shelf browser)

Previous	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	Next
Previous	MPHAR20010016c.2 A COMPARATIVE STUDY ON THE SEDATIVE ACTION OF LETTUCE (LACTUSA SATIVA) AND DIAZEPAM (VALIUM) ON MALE CATS	MPHAR20010017c.1 COMPARING THE ANTI-BACTERIAL EFFECTS OF SYZYGIUM CUMINII LINN. (DUHAT) LEAF EXTRACT WITH OXACILLIN ON STAPHYLOCOCCUS AUREUS	MPHAR20010017c.2 COMPARING THE ANTI-BACTERIAL EFFECTS OF SYZYGIUM CUMINII LINN. (DUHAT) LEAF EXTRACT WITH OXACILLIN ON STAPHYLOCOCCUS AUREUS	MPHAR20010021c.1 THE ANTIMUTAGENIC EFFECT OF SWEET POTATO (IPOMOEA BATATAS) ON MITOMYCIN-C INDUCED MALE ALBINO RAT	MPHAR20010021c.2 THE ANTIMUTAGENIC EFFECT OF SWEET POTATO (IPOMOEA BATATAS) ON MITOMYCIN-C INDUCED MALE ALBINO RAT	MPHAR20020001c.2 A COMPARATIVE STUDY OF THE ANTISEPTIC PROPERTY OF PSIDIUM GUAJAVA (GUAVA) AND POVIDONE-IODINE (BETADINE) ON WOUND HEALING OF SURGICALLY INCISED WOUNDS ON GUINEA PIGS (CAVIA SPP.)	MPHAR20020002c.1 A COMPARATIVE STUDY ON THE EFFECTS OF GARLIC (ALLIUM SATIVUM), INSULIN, AND COMBINATION OF BOTH ON BLOOD GLUCOSE LEVELS OF SWISS MICE	Next

Pharmacology Thesis

Cancer is one of the fatal diseases known to man. Economic status, culture, genetics and lifestyle are just some of the multifactorial contributors that come into play in the causation of the disease. Seeing the need for cheap and alternative or adjunct to current therapy, this study aims to demonstrate the antimutagenic effect of Ipomoea batatas (kamote) on Mitomycin-C-induced tats. In the experiment, 15 male albino rats were divided into 3 groups with 5 rats each After a week of acclimatization, Group 1 as the baseline negative was given NSS only, Group 2 was given Mitomycin-CC, and Group 3 was given Mitomycin-C and kamote extract After 3 days, the animals were sacrificed. The femurs were isolated and the bone marrow aspirated through syringe. The aspirate was smeared, air dried, stained, and then viewed under compound light microscope. The number of micronuclei was counted per 1,000 rbcs/slide as a measures of mutagenic effect. The values obtained were averaged and analyzed using Analysis of Variance (ANOVA) at F-distribution and Scheffe`s test with a confidence interval of 95%. The result showed that was a significant different between the three groups. There was a significant difference between the frequency of micronuclei in the rbc`s of the group of rats induced with Mitomycin-C and then given kamote extract than those of the group of rats from which kamote extract was witheld, with group 3 mice showing considerably less micronuclei. With the defined parameters for antimutagenicity, plus the demonstrated decrease in micronuclei count in group 3 rats, the researchers concluded the kamote extract as antimutagenic in Mitomycin-C-induced rats.

Department of Pharmacology

There are no comments on this title.

to post a comment.